The KSL/UB investigation led to the development of KSL’s COVID-19 Immune Index™ test, launched last month. Negative results for IgG indicated a lack of circulating antibodies that could represent a lack of immunity against COVID-19.Below IgG titers of 10, virus neutralization decreased considerably, suggesting inadequate immunity.IgG levels from 10 – 20 reduced effective virus neutralization by 25%.IgG titers of 20 and above demonstrated 100% neutralization of SARS-CoV-2, suggesting adequate immunity.Study results showed a correlation between COVID-19 antibody levels and virus neutralization with stratification of immunity: An additional consideration was developing a new assay suitable for high throughput testing that could be used to quickly assess immunity levels in a specific population to promote vaccine boosters as needed and inform healthcare policy. The aim of the study was to compare the semi-quantitative titers of a laboratory-developed SARS-CoV-2 spike antibody assay against the industry-standard plaque reduction neutralization test (PRNT) to determine if a specific circulating antibody titer is needed for optimal virus deactivation. The study was funded by a grant from the University at Buffalo Center for Advanced Technology in Big Data and Health Sciences (UB CAT). The presentation highlights the results of a SARS-CoV-2 study conducted by KSL and researchers at UB’s Jacobs School of Medicine and Biomedical Sciences. (KSL), developers of novel diagnostic and therapeutic applications for immunology and oncology, and the University at Buffalo (UB) will present a poster paper on “Correlation of Antibody Levels with SARS-CoV-2 Virus Neutralization” at the Congress of Clinical Rheumatology May 11-15 in Destin, FL.

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